School of Medicine

Wayne State University School of Medicine
Department of Pathology Bioactive Lipids Research Program
Dr. Kenneth V. Honn - Director

Post-Doctoral Opportunities

Position I: 
Postdoctoral/Research Associate Positions are available to conduct NIH and Department of Defense grant-funded research on prostate cancer. Our laboratory has been the pioneer in establishing the role of platelet-type 12-lipoxygenase in cancer and metastasis. Current research efforts are focused on the interaction of 12-lipoxygenase with β4-integrin and subsequent effects on cell adhesion, motility, invasion, and metastasis. In addition, the interaction of 12-Lipoxygnease with cytoskeletal elements and Lamin A are being investigated. Our studies are aimed at ultimately establishing novel therapeutic strategies for late stage prostate cancer. Applicants should possess a Ph.D. degree in cell and molecular biology, cancer biology, biochemistry, or related fields to qualify. Successful candidates are expected to possess excellent written and oral communication skills in English, good publication record, highly motivated with demonstrable experience in modern molecular biology and protein-protein interaction related techniques. Preference will be given to candidates with experience in bioactive lipids, cancer, and/or inflammation.

Position II: 
Postdoctoral/Research Associate Positions are available to conduct NIH and Department of Defense grant-funded research on prostate cancer. Our laboratory has been the pioneer in establishing the role of thromboxane in cancer progression and metastasis. Current research efforts are focused on the role of thromboxane synthase and thromboxane receptors (TPα and TPβ) in prostate cancer progression, motility, and invasion. A clinical study is currently underway to assess the role of thromboxane synthase metabolites as potential biomarkers in prostate cancer patients. Applicants should possess a Ph.D. degree in cell and molecular biology, cancer biology, biochemistry, or related fields to qualify. Successful candidates are expected to possess excellent written and oral communication skills in English, good publication record, highly motivated with demonstrable experience in modern molecular biology techniques and receptor mediated signal transduction. Preference will be given to candidates with experience in bioactive lipids, cancer, and/or inflammation.

Position III:
Postdoctoral/Research Associate Positions are available to conduct Department of Defense grant-funded research on prostate cancer. Our laboratory has identified a novel family of 7-transmembrane, G-protein coupled receptors with hydroxy polyunsaturated fatty acids as potential endogenous ligands. Efforts are underway to characterize the receptors, identify their down-stream signaling pathways, and evaluate their role in tumor angiogenesis. Applicants should possess a Ph.D. degree in cell and molecular biology, cancer biology, biochemistry, or related fields to qualify. Successful candidates are expected to possess excellent written and oral communication skills in English, good publication record, highly motivated with demonstrable experience in modern molecular biology techniques and receptor mediated signal transduction. Preference will be given to candidates with experience in bioactive lipids, cancer, and/or inflammation.

Interested persons should apply by sending a letter of interest, complete curriculum vitae, and list of recent peer reviewed publications. Letters of reference are required from three persons familiar with the candidates qualifications and research experience.  Salary levels will be commensurate with experience and qualifications.  Mail to:  Prof. Kenneth V. Honn  * Department of Pathology  * Wayne State University * 431 Chemistry Building * Detroit, MI 48202 * Email: k.v.honn@wayne.edu * Fax: 313-577-0798