School of Medicine

Wayne State University School of Medicine
Department of Pathology Bioactive Lipids Research Program
Dr. Kenneth V. Honn - Director

Past Research Projects

Kenneth V. Honn, Principal Investigator

1. Prostaglandins and Lysosomal Mediated Tumor Metastasis. WSU Research Development Fund. (P.I., K.V. Honn), 6/1/79 to 5/31/80, $6,760.
 
2. New Approach for the Control of Tumor Metastasis. The Milheim Foundation for Cancer Research. (P.I., K.V. Honn), 7/1/80 to 6/30/81, $12,000.
 
3. Evaluation of the Antimetastatic Effects of Bay g 6575. Miles Institute for Preclinical Pharmacology. (P.I. , K.V. Honn), 6/1/80 to 5/31/81, $3,000.
 
4. Studies on Prostacyclin and Tumor Metastasis. NIH/NCI – R01-CA29405-1 (P.I., K.V. Honn), 10/1/80 to 9/30/83, $104,787.
 
5. Studies on Thromboxane Synthetase Inhibitors and Cancer. Comprehensive Cancer Center of Metropolitan Detroit. (P.I., K.V. Honn), 10/1/80 to 9/31/81, $10,000.
 
6. Studies on Thromboxane Synthetase Inhibitors as Antimetastatic Agents. American Cancer Society. (P.I., K.V. Honn), 1/1/81 to 12/31/82, $94,151.
 
7. Thromboxanes: Role in Tumor Growth and Metastasis. NIH/NCI – R01-CA29997-1 (P.I., K.V. Honn), 4/1/81 to 3/31/84, $158,339.
 
8. Continuing Studies on the Antitumor Effects of BAY g 6575. Miles Institute for Preclinical Pharmacology. (P.I., K.V. Honn), 2/1/81 to 1/31/ 82, $59,000.
 
9. Studies on the Antimetastatic Effects of BAY g 6575. Miles Institute for Preclinical Pharmacology. (P.I., K.V. Honn), 2/1/81 to 1/31/82, $5, 060.
 
10. Continuing Studies on the Antitumor Effects of BAY g 6575. Miles Institute for Preclinical Pharmacology. (P.I., K.V. Honn), 2/1/82 to 1/31/83, $ 57,000.
 
11. Cancer Chemoprevention and Arachidonate Metabolism. NIH/NCI, R01 L.J. Marnett, K.V. Honn and B.F. Sloane, (P.I. L.J. Marnett), 8/1/82 to 7/31/85, $350,000.
 
12. Evaluation of the Antitumor and/or Antimetastatic Activities of CGS-13080 and CGS-14854. Ciba-Geigy Corporation. (P.I., K.V. Honn), 10/1/82 to 9/30/83, $14,460.
 
13. Evaluation of Antitumor and Antimetastatic Activities of Thromboxane Synthetase Inhibitors. Pfizer Corporation. (P.I., K.V. Honn), 10/1/82 to 9/30/83. $15,000.
 
14. Development of Monoclonal Antibodies to Cathepsin B. HarperGrace Hospitals. K.V. Honn and B.F. Sloane, (P.I., K.V. Honn), 7/1/83 to 8/31/84, $127,000.
 
15. Studies on Prostacyclin and Tumor Metastasis. NIH/NCI R01-CA29405-4 (P.I., K.V. Honn), 7/7/83 to 12/31/86, $189,183.
 
16. Cathepsin B-like Cysteine Proteinases and Tumor Invasion. NIH/NCI R01-CA36481-1. B.F. Sloane and K.V. Honn, (P.I.,B.F. Sloane), 12/1/83 to 11/30/86, $341,000.
 
17. Thromboxanes: Role in Tumor Growth and Metastasis. NIH/NCI R01 CA29997-4. (P.I.,K.V. Honn), 4/1/84 to 12/31/87, $341,113.
 
18. Studies on Metastasis. Harper/Grace Hospitals. K.V. Honn, L.J. Marnett and B.F. Sloane, (P.I., K.V. Honn), 1/1/85 to 63086, $160,000.
 
19. Studies on Metastasis.  Thomae Pharaceutical. K.V. Honn and L.J. Marnett (P.I., K.V. Honn), 1/1/85 to 12/31/85, $60,000.
 
20. Studies on Metastasis. Harper-Grace Hospitals. K.V. Honn, L.J. Marnett, B.F. Sloane, C.J. Johnson and J.M. Onoda (P.I., K.V. Honn), 12/1/85 to 8/31/87, $175,000.
 
21. Development of Lipoxygenase Inhibitors. Harper/Grace Hospitals. K.V. Honn, L. J. Marnett, C. Johnson (P.I. K. V. Honn), 9/1/87 to 6/30/89, $250,000 (direct costs).
 
22. Role of Platelets in Hematogenous Metastasis. American Cancer Society. (P.I., K.V. Honn), 1/1/86 to 12/31/87,  $190,000.
 
23. Role of Platelets in Hematogenous Metastasis. American Cancer Society.  K.V. Honn (P.I. K.V. Honn) Interim Funding 1/1/88 to 6/30/89, $48,000.
 
24. Studies on Radiporotection, Coagulation and Metastasis–Harper Grace Hospitals.  J. M. Onoda and K.V. Honn (P.I. K. V. Honn), 10/1/88 to 9/30/89, $100,297 (direct costs).
 
25. Studies on Metastasis. Thomae Pharmaceutical. K.V. Honn and L.J. Marnett, (P.I., K.V. Honn), 1/1/87 to 12/31/90, $60,000 (direct costs).
 
26. Tumor Cell Adhesive Glycoproteins and Metastasis. NIH/NCI – R01-CA47115-1 (P.I. K.V. Honn), 5/1/88 to 4/31/92, $418,323 (direct costs).
 
27. Studies on 12-Lipoxygenase–Ono Pharmaceuticals. K.V. Honn, C.R. Johnson, and L.J. Marnett (P.I. K.V. Honn).  1/1/89 to 12/31/92, $2,525,000 (direct costs).
 
28. Studies on Radiporotection, Metastasis–Harper Grace Hospitals.  J. M. Onoda and K.V. Honn (P.I. K. V. Honn), 1/1/90 to 12/31/93, $104,921 (direct costs).
 
29. Supplemental Equipment Grant for Metastasis Program–Harper Grace Hospitals.  J.M. Onoda and K.V. Honn (P.I. K.V. Honn), 5/1/91 to 9/30/94, $157,000 (direct costs).
 
30. Cathepsin B-like Cysteine Proteinases and Tumor Invasion. NIH/NCI Bonus Grant R01-CA36481-4. B.F. Sloane and K.V. Honn, (P.I., B.F. Sloane), 7/1/87 to 6/30/93, $493,046 (direct costs).
 
31. New Signal Transduction Pathways in Metastatic Melanoma Cells.  NATO Linkage Grant (P.I. K.V. Honn) 1/1/93 to 12/31/95, $26,000 (direct costs).
 
32. Signal Transduction in Tumor Metastasis. Fogarty International Research Collaboration Award.  (P.I. K.V. Honn) 9/1/93 to 8/31/96, $60,000 (direct costs).
 
33. Role of Endothelial Cell 12-Lipoxygenase and 12(S) HETE in Tumor Induced Angiogenesis.    Cancer Research Foundation of America (P.I.., K.V. Honn) 1/1/97 to 12/31/97, $25,000 (direct costs).
 
34. Role of Signaling in the Progression of Melanoma. NATO Linkage Grant (P.I., K.V. Honn)  1/1/95 to 12/31/97, $26,000 (direct costs).
 
35. Studies on Metastasis, Harper Hospital Development Fund (P.I. K.V. Honn), 9/1/94 - 8/30/98, $248,000 (direct costs).
 
36. Prognostic Markers for Prostate Cancer, Harper Hospital Development Fund, (P.I. K.V. Honn) 9/1/94 to 6/30/98, $99,000 (direct costs).
 
37. Metastatic Studies:  Potential Involvement of Integrin b in Tumor Progression and Metastasis). Harper Hospital Development, (P.I. K.V. Honn) 11/1/94 to 10/31/98, $100,000 (direct costs).
 
38. Tumor Cell Adhesive Glycoproteins and Metastasis. NIH/NCI.  R01CA47115-6, (P.I. K.V. Honn), 03/01/95 to 02/28/99, $1,178,331 (direct and indirect costs).
 
39. Role of Endothelial Cell 12-Lipoxygenase and 12(S) HETE in Tumor Induced Angiogenesis.    Cancer Research Foundation of America (P.I.., K.V. Honn) 04/15/97 to 04/15/99, $55,000 (direct costs).
 
40. Studies on Metastasis.  Harper Hospital Development Fund (P.I. K.V. Honn), 09/01/94 to 06/30/99, $248,000 (direct costs).
 
41. Prognostic Markers for Prostate Cancer. Harper Hospital Development Fund (P.I. K.V. Honn), 09/01/94 to 06/30/99, $99,000 (direct costs).
 
42. Bioactive Lipids:  Role in Prostate Cancer Angiogenesis.  DOD/Army  (P.I., K.V. Honn) 9/30/98 to 3/30/01, $468,750 (direct and indirect costs).
 
43. Arachidonate Acid 12-Lipoxygenase Inhibitors for Anti-Angiogenesis Therapy of Prostate Cancer.  CAPCure (P.I. KV Honn), 01/01/99 to 12/31/01, $75,000.
 
44. Role of Eicosanoids in Tumor Cell Metastasis. NIH/NCI. CA R0129997, (P.I. K.V. Honn), 02/01/96 to 01/31/00, $988,291.
 
45. Development Grant - PCa Progression and Metastasis, NIH/NCI.  CA1R21 69845-01 (P.I. K.V. Honn) 09/01/95 - 08/31/01, $1,028,820 (direct costs).
 
46. Bioactive Lipids:  Role in Prostate Cancer Angiogenesis, Part II.  DoD Army-Phase II (competitive renewal) (P.I. K.V. Honn)  6/30/01 - 6/29/03, $552,276 (direct + indirect costs).

47. Ectopic Expression of Platelet Integrin aIIbb3 and the Progression of Human Melanoma.  NATO Linkage Grant (P.I. K.V. Honn), 04/15/99 to 03/31/2001, $11,500 (direct costs).
 
48. Thromboxane Synthase as a Target for Anti-Angiogenesis Therapy of Prostate Cancer.  Cancer Research Foundation of America.  (P.I. K.V. Honn)  4/15/01-4/14/03,  $60,000 (direct costs only).

49. Randomized Clinical Trial of Zileuton in Persons with Bronchial Dysplasia, NIH/NCI – Contract NO1-CN-05022 (O. Kucuk, H. Pass, T. Budd, K.V.Honn (P.I. O. Kucuk) ), 9/01/01-9/01/05, $1,402,882 (total direct).  
 
50.  Thromboxane Synthase and Prostate Cancer Progression, DoD/Army, (P.I. K.V. Honn), 12/1/01 - 07/15/05, $558,750.

51.  Formulation and Evaluation of a Prostate Cancer Drug, Phase 1, NIH STTR Phase 1 – 1 R41 CA97863-01 (P.I. K.V. Honn), 10/01/02-2/28/06, $148,000.

52.   Formulation and Evaluation of a Prostate Cancer Drug, Phase 1, NIH STTR Phase 1 – 1 R41 CA97863-01 (P.I. K.V. Honn), 10/01/02-2/28/06, $148,000.
 
53.  Eicosanoid Regulation of Prostate Cancer Progression:  Disruption of Hemidesmosomes and Collaboration in Tumor Invasive Growth, Department of Defense – DAMD17-03-1-0102 (P.I. K.V. Honn), 4/01/03-3/31/07, $ 558,472.
 
54.  Naturally Occurring Truncated b3 Integrins (aIIbb3 and avb3) In Prostate Cancer Metastasis. -Department of Defense - W81XWH-04-1-0144 (P.I. Rongxian Jin), Postdoctoral Traineeship Award, 01/01/04 - 1/31/07, $98,000.
 
55.  Faculty Graduate Research Assistantship. Wayne State University (Internal) (P.I. K.V. Honn),  Stipend for graduate student, 8/15/05 - 08/14/06,  $20,500.
 
56.  Tumor Cell Adhesive Glycoproteins and Metastasis.  NIH/NCI – 2 R01 CA47115-09A2 (P.I. K.V. Honn) (competitive renewal), 8/01/01-7/31/06, $1,487,060.
 
57. 12-Lipoxygenase as a Target for Radiosensitization, NIH/STTR – 1 R41 CA103564-01A2  (P.I. K.V. Honn), 04/01/05 – 03/31/07, $99,744 (direct and indirect costs).

58.  Role of Eicosanoids in Tumor Cell Metastasis. NIH – 5 R01 CA029997-18 (P.I. K.V. Honn). 4/01/04-3/31/10, $1,359,00 (direct and indirect costs).

59.  Characterization of a Novel 12(S)-HETE Receptor and Role in Prostate Cancer Progression. DOD – W81XWH-06-1-0226 (P.I. K.V. Honn), 12/30/05 - 1/30/10, $565,398 (direct and indirect costs).

60.  12-Lipoxygenase and Prostate Cancer Angiogenesis.  Fund for Cancer Research (P.I. K.V. Honn), 08/15/07 – 08/14/10, $75,000 (no indirects).

61.  Role of Thromboxane in Prostate Cancer Progression.  NIH/NCI – 1 R01 CA114051-01A1 (P.I.  K.V. Honn), 08/15/06 – 07/31/11, $1,618.313 (direct and indirect costs).

62. 12-Lipoxygenase-Induced Prostate Cancer Angiogenesis and Resistance to Antiangiogenic Therapy.  DOD (P.I. K.V. Honn), 09/01/08 – 09/30/11, $563,494 (direct and indirect costs).

63.  Role of GPR31, a high-affinity receptor of 12(S)-HETE, in prostate cancer progress. Fund for Cancer Research,  (P.I.: Honn, K.V). - Period 6/1/11 – 5/30/12- $75,000 (no indirects)

 

 Krishnarao Maddipati, Principal Investigator

  1. Purification and Crystallization of Human 12-LOX Enzymes. NIH/STTR (P.I. K. Maddipati), 9/1/04 - 9/30/05, $99,864.
  2. Anticancer Prodrug Developement Program. Michigan Technology Tri-Corridor (P.I. K.Maddipati), 9/1/05- 8/31/08, $569,977.