Krishna Rao Rao Maddipati PhD

Professor & Director
Lipidomics Core Facility
maddipati@wayne.edu
435 Chemistry Bldg.
Detroit, Michigan 48202
Phone: 313-577-2088
Fax  313-577-0798

Education

B.Sc., Andhra University, India, 1975
Major: Chemistry, Minor: Biology

M.Sc., Kurukshetra University, India, 1977
Specialization: Organic Chemistry

Ph.D., Indian Institute of Science, India, 1983
Dissertation: "Microbial degradation of sterol side chains"

Research Interests

Biochemistry and chemistry of bioactive lipids, PUFA metabolism, Lipidomics, Eicosanoid enzymology, Anticancer agents in dietary ingredients, and Anticancer drug development targeting lipoxygenases

Curriculum Vitae

Training: Jan. 1983 - Aug. 1983: Research Associate, Dept. of Science and Technol., Indian Institute of Science, Bangalore, India
Aug. 1983 - Aug. 1985: Research Associate, The Pennsylvania State University, University Park, PA 16802
Aug. 1985 - Dec. 1987: Research Associate, Department of Chemistry, Wayne State University, Detroit, MI 48202

Professional Appointments:
Jan. 1988 - July 1989: Research Scientist, Department of Chemistry, Wayne State University, Detroit, MI 48202
Aug. 1989 - March 2001: Director, Research and Development Cayman Chemical Company, Ann Arbor, MI 48108
Oct. 2001-July 2007: Assistant Professor (Research), Radiation Oncology, Wayne State University, Detroit, MI 48202
July 2007-August 2015: Assistant Professor (Research), Pathology, Wayne State University, Detroit, MI 48202
September 2011-Present: Director, Lipidomics Core Facility, Pathology, Wayne State University, Detroit, MI 48202
September 2015-August 2021: Associate Professor (Research), Pathology, Wayne State University, Detroit, MI 48202

August 2021 - Present: Professor (Research), Pathology, Wayne State University, Detroit, MI 48202

Grant Support:

Past:
Triple Quadrupole - Ion Trap Hybrid LC/MS/MS System, NIH, P.I.: K. R. Maddipati, Period: 04/22/2010 - 04/21/2011, $425,329. Purification and crystallization of human 12-LOX enzymes. NIH, P.I.: K. R. Maddipati, Period: 09/01/2004 - 08/30/2006, $101,295. Anticancer Prodrug Development Program. Michigan Technology Tri-Corridor (MTTC), P.I.: K. R. Maddipati, Period: 10/01/05 - 09/30/08, $569,977.
Structural Characterization of Human Plasma Glutathione Peroxidase. WSU Molecular Biology Center, P. I. K. R. Maddipati, 8/1/1987 to 7/31/1988, $19,385.
Enzyme Immunoassay for 8-iso-2,3-dinor prostaglandin F1α - Development of Specific Antibodies. NIEHS, P. I. K. R. Maddipati, 5/15/1998 to 11/14/1998, $99,871.

Representative Publications:

  1. Maddipati KR. Non-inflammatory Physiology of "Inflammatory" Mediators - Unalamation, a New Paradigm. Front Immunol. 2020;11:580117. PubMed Central PMCID: PMC7575772.
  2. Norris PC, Skulas-Ray AC, Riley I, Richter CK, Kris-Etherton PM, Jensen GL, Serhan CN, Maddipati KR. Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation. Sci Rep. 2018 Dec 21;8(1):18050. PubMed Central PMCID: PMC6303400.
  3. Sevinsky CJ, Khan F, Kokabee L, Darehshouri A, Maddipati KR, Conklin DS. NDRG1 regulates neutral lipid metabolism in breast cancer cells. Breast Cancer Res. 2018 Jun 14;20(1):55. PubMed Central PMCID: PMC6001025.
  4. Kim SN, Akindehin S, Kwon HJ, Son YH, Saha A, Jung YS, Seong JK, Lim KM, Sung JH, Maddipati KR, Lee YH. Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice. Sci Rep. 2018 Jun 11;8(1):8856. PubMed Central PMCID: PMC5995961.

Complete List of Published Work in My Bibliography.