School of Medicine

Wayne State University School of Medicine
Department of Pathology Bioactive Lipids Research Program
Dr. Kenneth V. Honn - Director

Profile

Keqin Tang, M.D., Ph.D. MD, PhD


Assistant Professor


Research Interests

Clinical translation studies in prostate and lung cancer, eicosanoids and lipoxygenase regulation of carcinoma progression, integrins and 12-lipoxygenase interactions in cancer and psoriasis, androgen receptor regulation by lipoxygenase especially in apoptosis and signaling mechanism.

Curriculum Vitae

Tang, K., 1990. The application of monoclonal antibody in the diagnosis and therapy of tumor. Post Graduate Journal of Jinan University. 6(1):87.

Tang, K., Situ, R., and Zeng, Y.Y. 1992. Synergetic effects of phorbol ester and laminin invasible potential of CNE-2z cells. The Journal of China Pathology. 21(5):310.

Tang, D.G., Grossi, I.M., Tang, K., Diglio, C.A., and Honn, K.V., 1995. Inhibition of TPA
and12(S)HETE-stimulated tumor cell adhesion by prostacyclin and its stable analogs: Rationale for their antimetastatic effects. Int.J.Cancer, 60:418-425.

Trikha, M., Timar, J., Tang, K., and Honn, K.V., 1996. Human prostate carcinoma cells express functional ?IIb?3 integrin. Cancer Research, 56: 5071-5078.

Tang, K. and Honn, K.V. 1997. Lipoxygenase metabolites and cancer metastasis. Adv Exp Med Biol. 422:71-84.

Nie, D., Hillman G.G., Geddes, T., Tang, K., Pierson, C., Grignon, D.J., and Honn, K.V. 1998. Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth. Cancer Research, 58: 4047-4051.

Tang, K. and Honn, K.V. 1999. 12(S)-HETE in cancer metastasis.
Adv Exp Med Biol. 447:181-91.

Tang, K., Nie, D., Cai, Y., and Honn, K.V. 1999. The ?4 integrin subunit rescues A431 cells from apoptosis through a PI3K/Akt kinase signaling Pathway. Biochem Biophy Res Comm. 264: 127,132.

Nie, D., Hillman, G.G., Geddes, T., Tang, K., Pierson, C., Grignon, D.J. and Honn, K.V. 1999, Platelet-type 12-lipoxygenase regulates angiogenesis in human prostate carcinoma. Adv Exp Med Biol. 469:623-30.

Tang, K., Nie, D. and Honn KV. 1999. Role of autocrine motility factor in a 12-lipoxygenase dependent anti-apoptotic pathway. Adv Exp Med Biol. 1999;469:583-90.

Nie, D., Tang, K., Digio, C., and Honn, K.V. 2000. Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase. Blood. 95:2304-2311.

Nie, D., Lamberti, A., Zacharek, A., Li, L., Szekeres, K., Tang, K., Chen, Y., and Honn, K.V. 2000. Thromboxane A2 regulation of endothelial cell migration, angiogenesis and tumor metastasis. Biochem Biophys Res Comm. 267: 245-251.

Tang, K., Finley, R.L. Jr., Nie, D., and Honn, K.V. 2000. Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening. Biochemistry. 39: 3185-3191.

Szekeres, K., Tang, K., Trikha, M., and Honn, K.V. 2000. Eicosanoid activation of extracellular signal-regulated kinase 1/2 in human epidermoid carcinoma cells. J Biol Chem. 275: 38831-38841.

Nie, D., Tang, K., Szekeres, K., Li, L., and Honn, K.V. 2000. Eicosanoid regulation of angiogenesis in human prostate carcinoma and its therapeutic implications. Ann N Y Acad Sci. 95: 165-167.

Nie, D., Lamberti, M., Zacharek, A., Li, L., Szekeres, K., Tang, K., Chen, Y., and Honn, K.V. 2000. Thromboxane A (2) regulation of endothelial cell migration, angiogenesis, and tumor metastasis. Biochem Biophys Res Commun. 267: 245-251.

Nie, D., Tang, K., Szekeres, K., Trikha, M. and Honn, K.V. 2000. Role of eicosanoids intumor growth and metastasis. Advances in Eicosanoid Research (C.S.Serhan, ed) Spring, Berlin. pp201-217.

Nie, D., Che, M., Grignon, D., Tang, K. and Honn, K.V. 2001. Role of eicosanoids in prostate cancer progression. Cancer and metastasis Review. 20:195-206.

Pidgeon, G.P., Tang, K., Rice, R.L., Li, L., Taylor, J.D., and Honn, K.V. 2003. Over-expression of leukocyte-type 12-lipoxygenase promotes W256 tumor cell survival by enhanced avb5 expression. Internal J. Cancer. 105:459-271.

Pidgeon, G.P., Tang, K., Cai, Y., Piasentin, E., and Honn, K.V. 2003. Over-expression of platelet- type 12-lipoxygenase promotes tumor survival by enhancing vitronectin-specific integrin expression. Cancer Res. 63: 4258-4267.

Nie, D., Nemeth, J., Qiao, Y., Tang, K., Hilman, G.G., Cher, M., Grignon, D., and Honn, K.V 2003. Increased metastatic potentials in human prostate carcinoma cells by Overexpression of arachidonate 12-Lipoxygenase. Clin Exp Metastasis. 20: 657-663.

Nie, D., Che, M., Zacharek, A., Qiao, Y., Li, L., Lamberti, M., Tang, K., Cai, Y., Guo, G., Grignon, D., and Honn, K.V. 2004. Differential expression of thromboxane synthase in prostate carcinoma: Role in tumor cell motility. American Journal of Pathology. 164: 429-439.

Tang, K., Finley Jr., R.L., Nie, D., Cai, Y., Lamberti, M.P., Fridman, R., Carey, T.E., Crissman, J.D., and Honn, K.V. Regulation of Arachidonate 12-Lipoxygenase by physical interaction with Integrin ?4 Subuint. (in preparation for re-submission)

Tang, K., Nie, D., Cai, Y.L., Lamberti, M.P., and Honn, K.V. 12-Lipoxygenase effects on androgen-stimulated prostate cancer cell growth and motility. Manuscript in preparation