School of Medicine

Wayne State University School of Medicine
Department of Pathology Bioactive Lipids Research Program
Dr. Kenneth V. Honn - Director

Profile

Krishna Rao Rao Maddipati PhD


Associate Professor & Director, Lipidomics Core Facility
(313) 577-2088
maddipati@wayne.edu
435 Chemistry Bldg., Detroit, Michigan 48202

Fax

(313) 577-0798

Education

B.Sc., Andhra University, India, 1975
Major: Chemistry, Minor: Biology
 
M.Sc., Kurukshetra University, India, 1977
Specialization: Organic Chemistry
 
Ph.D., Indian Institute of Science, India, 1983
Dissertation: "Microbial degradation of sterol side chains"

Research Interests

Biochemistry and chemistry of bioactive lipids, PUFA metabolism, Lipidomics, Eicosanoid enzymology, Anticancer agents in dietary ingredients, and Anticancer drug development targeting lipoxygenases


Curriculum Vitae

Training:

Jan. 1983 - Aug. 1983: Research Associate, Dept. of Science and Technol., Indian Institute of Science, Bangalore, India
Aug. 1983 - Aug. 1985: Research Associate, The Pennsylvania State University, University Park, PA 16802
Aug. 1985 - Dec. 1987: Research Associate, Department of Chemistry, Wayne State University, Detroit, MI 48202
 
Professional Appointments:
 Jan. 1988 - July 1989: Research Scientist, Department of Chemistry,
Wayne State University, Detroit, MI 48202
Aug. 1989 - March 2001: Director, Research and Development
Cayman Chemical Company, Ann Arbor, MI 48108
Oct. 2001-July 2007: Assistant Professor (Research), Radiation Oncology, Wayne State University, Detroit, MI 48202
July 2007-August 2015: Assistant Professor (Research), Pathology, Wayne State University, Detroit, MI 48202
September 2011-Present: Director, Lipidomics Core Facility, Pathology, Wayne State University, Detroit, MI 48202
September 2015-Present: Associate Professor (Research), Pathology, Wayne State University, Detroit, MI 48202
 
Grant Support:
Past:
Triple Quadrupole - Ion Trap Hybrid LC/MS/MS System, NIH, P.I.: K. R. Maddipati, Period: 04/22/2010 - 04/21/2011, $425,329.
 Purification and crystallization of human 12-LOX enzymes. NIH, P.I.: K. R. Maddipati, Period: 09/01/2004 - 08/30/2006, $101,295.
 Anticancer Prodrug Development Program. Michigan Technology Tri-Corridor (MTTC), P.I.: K. R. Maddipati, Period: 10/01/05 - 09/30/08, $569,977.
Structural Characterization of Human Plasma Glutathione Peroxidase. WSU Molecular Biology Center, P. I. K. R. Maddipati, 8/1/1987 to 7/31/1988, $19,385.
Enzyme Immunoassay for 8-iso-2,3-dinor prostaglandin F1α - Development of Specific Antibodies. NIEHS, P. I. K. R. Maddipati, 5/15/1998 to 11/14/1998, $99,871.
 
Representative Publications:

a.     Maddipati KR, Zhou SL. Stability and analysis of eicosanoids and docosanoids in tissue culture media. Prostaglandins Other Lipid Mediat. 2011 Feb;94(1-2):59-72. PubMed PMID: 21236355.

b.     Maddipati KR, Romero R, Chaiworapongsa T, Chaemsaithong P, Zhou SL, Xu Z, Tarca AL, Kusanovic JP, Gomez R, Chaiyasit N, Honn KV. Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up-regulation of leukotriene B4.FASEB J. 2016 Oct;30(10):3296-3307. Epub 2016 Jun 16. PubMed PMID: 27312808; PubMed Central PMCID: PMC5024690.

c.     Maddipati KR, Romero R, Chaiworapongsa T, Chaemsaithong P, Zhou SL, Xu Z, Tarca AL, Kusanovic JP, Gomez R, Docheva N, et al. Clinical chorioamnionitis at term: the amniotic fluid fatty acyl lipidome. J Lipid Res. 2016 Oct;57(10):1906-1916. Epub 2016 Aug 18. PubMed PMID: 27538821; PubMed Central PMCID: PMC5036371.

d.     Maddipati KR, Romero R, Chaiworapongsa T, Zhou SL, Xu Z, Tarca AL, Kusanovic JP, Munoz H, Honn KV. Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor. FASEB J. 2014 Nov;28(11):4835-46. PubMed PMID: 25059230; PubMed Central PMCID: PMC4200329

Complete List of Published Work in My Bibliography:
http://www.ncbi.nlm.nih.gov/myncbi/krishnarao.maddipati.1/bibliography/40084100/public/?sort=date&direction=ascending